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DeRidder and Goldsbrough Reference DeRidder and Goldsbrough2006)

Andrographolide inhibits CYP3A4 activity by binding and antagonizing PXR function, and is a potential CYP3A4 inhibitor that may have clinical significance (Ooi et al., 2011)

doi: 10.1016/j.neulet.2019.134386

However, several factors complicate vitamin A therapy in the setting of alcoholism: It is difficult to assess how much vitamin A actually is stored in the tissues, because vitamin A in the blood does not necessarily reflect levels in the liver

This means that if the body's demand for carnitine exceeds its ability to synthesize enough carnitine to meet that demand, then the body will require carnitine from outside sources, such as through diet or supplementation -- otherwise performance and health may suffer