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Preclinical: With increased knowledge of the nose-brain pathway and IN therapeutics, IN-BDNF to mouse models of depression is being explored: in a chronic mild stress (CMS) induced-depression model, mice were given AAV-packaged BDNF fused with cell-penetrating peptides, human immunodeficiency virus-1 transactivator of transcription (TAT), and influenza A hemagglutinin glycoprotein 2 (HA2)

They also meet validated manufacturing standards such as Good Manufacturing Practice (GMP)

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The most commonly reported side effects include: Pain, bruising, or redness at the injection site Mild nausea or stomach upset Diarrhea Headache Allergic reaction (rare) Because MIC injections are compounded formulations, the quality and composition can differ from one clinic to another

Allergic Reactions In rare cases, individuals may experience an allergic reaction to Glutathione IV therapy