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Additional assays commonly measure fatty acid oxidation rates, intracellular lipid accumulation, and downstream signaling intermediates such as cyclic AMP and protein kinase A activation

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In brief, molecule 356 was the best candidate to inhibit MAO-A, due to its high affinity for MAO-A ( 12.9 kcal/mol), and low affinity energy for MAO-B ( 8.8 kcal/mol), which indicates good selectivity