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pH-responsive systems exploit the acidic tumor microenvironment (pH 5.56.8 versus physiological pH 7.4) using ionizable groups (amines, carboxylates) or acid-labile linkages (hydrazones, acetals) that trigger drug release upon protonation or bond cleavage [15, 16]

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Another study [130] revealed the critical role of serine hydroxymethyltransferase-2 (SHMT2) in PTC metastasis, showing that SHMT2 is elevated in PTC and is associated with a poor prognosis

Evolutionary trees infer their kinship based on the similarity of gene sequences, with closer branches meaning closer relatives, higher sequence similarities, and closer cumulative branch lengths indicating closer kinship (as shown in Figure 3)