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Furthermore, M1 macrophages generate abundant ROS and secrete pro-inflammatory cytokines (e.g., TNF-, IL-6), which propagate lipid peroxidation and impair antioxidant mechanisms in neighboring structural cells (127)

Advancing neuroprotective therapies in PD will not only impact millions of patients worldwide but also yield valuable insights applicable to other disorders marked by neuronal loss

1 Metabolism of [3- 13 C]Ser in WT and TR/GR-null livers

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For example, MTF1 promotes ATP7B expression by binding to the MRE in the promoter region of ATP7B to promote Wilsons disease caused by copper overload (80)