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- **Treatment history**: Records should note an unsatisfactory response to oral iron therapy or intolerance, as well as whether the patient requires supplemental iron to maintain iron balance

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This is especially beneficial for those who may struggle to get adequate B12 through diet alone, including vegetarians, vegans, or those with certain digestive issues

This sequential approach allows clear identification of which agent causes any adverse effects that emerge

2 Vitamin B12 plays several important roles in the body, including: 3 Helping to produce energy by converting food into glucose Maintaining healthy nerve function Making DNA, the genetic material in all cells Helping to form red blood cells Helping enzymes to function as a cofactor Controlling homocysteine levels Vitamin B12 deficiency can lead to several health problems, including anemia, nerve damage, and neurologic symptoms such as memory loss and difficulty concentrating