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These findings demonstrate that sulfation efficiency is substantially higher in humans, underscoring species-specific enzymatic differences that are critical for accurate preclinical-to-human extrapolation (Ottaviani et al., 2016)

Open 42 HanssonO.ZetterbergH.BuchhaveP.LondosE.BlennowK.MinthonL

All studies that did not fulfil all eligibility criteria were excluded from further analysis

Disease course varies, with some patients experiencing spontaneous remission and others developing chronicity (Fig

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