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Activation of mTOR in senescent cells contributes to cellular dysfunction and the pro-inflammatory SASP.134 Inhibition of mTOR has been shown to reduce the expression of SASP factors and improve tissue function in animal models of aging.135 Modulation of the SASP: Senescent cells secrete a variety of pro-inflammatory cytokines, chemokines, growth factors, and proteases collectively known as the SASP
Pajno GB, La Grutta S, Barberio G, Canonica GW, Passalacqua G (2002) Harmful effect of immunotherapy in children with combined snail and mite allergy
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