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The possible reason Frontiers in Bioengineering and Biotechnology | www.frontiersin.org 7April 2021 | Volume 9 | Article 677576 fbioe-09-677576 April 24, 2021 Time: 18:16 # 8 Huang et al

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Because aryl esters are more easily hydrolyzed, they function more readily as prodrugs, with the ability to modify rates of hydrolysis by varying the substituent pattern [14]

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