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Description
The underlying driver is chronic inflammationspecifically, dysregulated immune signaling involving TNF-, interleukins (IL-17, IL-23), and NF-B pathways

After treated with Hsp90 inhibitors, HSV polymerases is mislocalized from the nucleus to the cytoplasm and subsequently degraded in a proteasome-dependent manner

doi: 10.1056/NEJMoa030660

The G and H sites of the enzyme are quite mobile when the crystal structure is determined, suggesting that the GST subunits undergo significant conformational changes on binding the substrates

aeruginosa strains isolated from human skin and soft tissue