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These responses can be additionally differentiated in a cell-specific manner due to the presence of nine known subtypes of those receptors, 1 (1A, 1B, 1D), 2 (2A, 2B, 2C), and ( 13) [78]

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However, based on data in excitotoxic stroke models, it is possible that compounds to enhance synaptic, GluN2A NMDARs may show neuroprotective benefit against NMDAR excitotoxicity and may be a promising next step in the search for better HD therapeutics, especially if used in conjunction with extrasynaptic GluN2B antagonism