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No long-term safety or efficacy data exists
If such a vicious cycle of glutamate excitotoxicity, oxidative stress, and mitochondrial dysfunction does indeed underpin ME/CFS pathology, it may not be clear where exactly the root problem lies
In addition, the application of edaravone has been expanded to include acute ischemic stroke, with a Phase III clinical trial underscoring the enhanced efficacy of edaravone when combined with dexborneol, suggesting the merits of this combined approach (36)
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