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Seeds-and-soil inspired hydrogel microspheres: a dual-action antioxidant and cellular therapy for reversing intervertebral disc degeneration

By analyzing the aortic tissue, we found that FOXO4-DRI treatment significantly increased the expression levels of Ki-67 and Lamin B, while reducing the expression of P21, P16, and -H2AX, similar to the results obtained from naturally aged mice (Figure 2A)

however, similar responses were given by high- and low-caffeine consumers ( p = 0.256)

This has drawn increasing interest in the potential therapeutic use of anti-coagulants in the treatment of IR injury 25

The global obesity epidemic and its associated metabolic disorders urgently require more effective therapeutic interventions, particularly multi-pathway targeting therapies