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Anticoagulants have a broad range of actions that act on the coagulation system, each of which can lead to different side effects

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CCL2 and colony stimulating factor (M-CSF/CSF1) derived from monocytes/macrophages may have a direct fibrotic effect (Coward et al., 2010)

However, none of the patients enrolled in this study was overweight (BMI = 17.0 4.4 kg/m 2 ), and the lean body mass did not differ between the congenital hypothyroid patients and the healthy controls (data not shown), suggesting that the hepatocytes might be the primary site of TG deposition in these patients