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ROS also attack unsaturated fatty acids in cell membranes and lipoproteins, triggering lipid peroxidation that compromises membrane integrity and fluidity [109]

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However, we did not find well-defined HSE sequences in the promoters of XBP1, HSPA5, or other canonical UPR genes

Pharmacological inhibition of C5aR1 by both treatments effectively counteracted the onset of HSRs abolishing paclitaxel-induced increase of vascular leakage and plasma extravasation (Fig
