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A redox-triggered bispecific supramolecular nanomedicine based on peptide self-assembly for high-efficacy and low-toxicity cancer therapy

10.1016/s0009-9120(02)00397-1 Clin Biochem

There are ample PRXs and GPXs present in the cytosol and mitochondria that convert H 2 O 2 or organic hydroperoxides, such as t -butyl hydroperoxide, to water or the corresponding alcohol

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Drp1 and several other proteins, such as Fis1 and mitochondrial E3 ubiquitin ligase MARCH5, in the mitochondrial fission machinery also appear to enhance the permeabilization of the mitochondrial outer membrane, with a resultant release of cytochrome c from the intermembrane space into the cytosol (Suen et al., 2008)