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Iron metabolism within cells involves the regulated uptake and storage of iron, with proteins such as transferrin, STEAP3, DMT1, and ferritin ensuring iron is appropriately managed to prevent oxidative damage

Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, Tran H, Ross SE, Mostoslavsky R, Cohen HY: Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

Without this active form of B12, homocysteine cannot fully recycle back to Methionine nor go down the transsulfuration pathway to become glutathione

PMID: 136 HuangW.-J.ZhangX.ChenW.-W

FIGURE 4 FIGURE 5 NAT-2, is a human enzyme also known as arylamine N-acetyltransferases-2 and is predominantly expressed in the liver and gastrointestinal tract (Windmill et al., 2000)