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It is known to provide a physiologically acceptable electrical current(0.1-1.0 mA/cm 2 ) using an electrode of the same polarity to drive charged permeants across the SC through its potential gradient [249, 250]

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Then appear the markers of OS associated with reduced activity of superoxide dismutase and the increase in glutamine, followed by increases of OH and the production of peroxides which ultimately has a negative impact on myelin