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the dimer interface which encompasses the inter-domain linker amino acids (K122, D123, Y124, 1125, R126, and N127) is referred to as the hinge region

This balancing effect is why Ta1 can be useful in both immunodeficiency (where the immune system is too weak) and certain autoimmune contexts (where the immune system is misdirected)

Emerging evidence demonstrates that non-malignant CAFs can contribute to tumor proliferation, metastasis, and chemoresistance

doi: 10.1016/j.tjo.2011.09.001
