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2021, Newsholme et al

These factors can increase or decrease gene transcription and thus increase or decrease the generation of new receptors (up- or down-regulation) that travel to the cell membrane

Excess iron accumulation is linked to oxidative damage in AD, PD, and other neurodegenerative diseases [173, 174]

doi: 10.1093/bib/bbae417

Also preferred is a nucleic acid molecule wherein said sequence of contiguous nucleotides is included in the nucleotide sequence of SEQ ID NO:1 in the range of positions beginning with the nucleotide at about the position of the 5 NT of Start Codon of ORF and ending with the nucleotide at about the position of the 3 NT of ORF as defined for SEQ ID NO:1 in Table I