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Atomic resolution structural studies have identified that the NACore region S 68 78 can form symmetrical cross beta-sheet folds, stabilising peptides in the misfolded fibril in a -sheet conformation [53]

Therefore, it is plausible that inhibiting FAox when TCA activity is already low and GSSG already high has no further effect, potentially explaining why fibroblasts are refractory to protection by ET

10.1038/EMM.2016.6 Exp Mol Med

Healthcare professionals should refer to MHRA guidance on the supply of unlicensed medicinal products ('specials') and GMC prescribing guidance for further detail