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[DOI] [PMC free article] [PubMed] [Google Scholar] Genois MM, et al

Spotlight on iron and ferroptosis: research progress in diabetic retinopathy

Never go overboard and apply too much serum

improved Fer-1s plasma stability by replacing the ethyl ester with a tert-butyl ester and adding an imine, yielding SRS16-86 (EC50 = 350 nM) with enhanced stability but reduced activity due to weaker target binding (Linkermann et al., 2014)

In the cell culture model of Wilsons disease, excessive copper accumulation unleashed a cascade of cellular stress responses, including autophagy, oxidative stress, and inflammation driven in part by the dysregulation of key signalling hubs such as NFKB and AP1