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Second, a reduction in tubular reabsorption of both free carnitine and acylcarnitine has been reported during VPA treatment [45,46], Third, VPA reduces endogenous synthesis of carnitine by blockade of the enzyme butyrobetaine hydroxylase

& Wanders, R.J.A

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However, these side effects are usually mild and go away within a few days

When using chemotherapy as treatment, it can cause carnitine deficiencies in the body
