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While these studies highlight the neuroprotective potential of CQDs in controlled assays, HEWL is a model protein with limited structural homology to disease-relevant aggregates, and the in vitro assays do not fully reflect neuronal environments

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The presence of high concentrations of tyrosine in the locus coeruleus and the substantia nigra leads to increased melanin synthesis which confers on these brain regions a dark bluish coloration observable in brain sections

The committee's recommendation, while not binding, is heavily weighted in the agency's subsequent decision on permanent listing