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It functions as an AR agonist and has been extensively investigated in studies of receptor binding dynamics, ligand-receptor interactions, transcriptional regulation, and AR-mediated signaling mechanisms

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The GRAS determination was likely based on the compound's limited systemic absorption (when ingested), short plasma half-life, and lack of acute toxicity signals in the Phase 2b obesity trial

Phase 5: maintenance dose (weeks 17 and beyond) Semaglutide dose: 2.0 to 2.4 mg per week This is the maximum dose range used in clinical trials for weight management