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The opening of the mitochondrial permeability transition pore (mPTP) may be responsible for the reduction in membrane potential [155]

These latter genera harbor sophisticated genetic arsenals encoding pivotal tryptophan metabolism enzymes (including tryptophan synthase K16187, indoleamine-2,3-dioxygenase IDO K00463, and tryptophan-2,3-dioxygenase TDO K00453) and their corresponding enzymatic machinery (EC:1.13.11.52 and EC:1.13.11.11), which systematically amplify tryptophan metabolite biosynthesis, thereby exponentially accelerating renal fibrotic progression trajectories

doi: 10.3390/ijms22084162

This is not unique to DSIP

M., Gardner, K