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Overview of IR The metabolites of chronic overnutrition, such as high glucose and non-esterified fatty acids (NEFAs), interfere with the activation of insulin receptor and its subsequent IRS-1/PI3K/Akt2 pathways, leading to the development of chronic inflammation in adipose tissue and ectopic lipid deposition in the liver and muscles, along with ERS and oxidative stress, etc

10.1016/j.psyneuen.2019.104578 Psychoneuroendocrinology 139 JunkerV.BeckerA.HhneR.ZembatovM.RavatiA.CulmseeC.et al (2002)

Apolipoprotein E and oxidative stress in brain with relevance to Alzheimers disease

The use of silymarin in the treatment of liver diseases

In this study, we use EGCG (()-epigallocatechin-3-gallate), the major catechin from green tea [32], as a safe and well-studied Nrf2 activator in combination with nicotinamide to restore the levels of GTP