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Am J Pathol 148: 225232 [PMC free article] [PubMed] [Google Scholar] Uehara Y., Minowa O., Mori C., Shiota K., Kuno J., Noda T., et al

Looking toward future research directions, attention should focus on long-term safety assessment of DPP1 inhibitors, biomarker development, optimal dosage determination, and combination treatment strategies

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Although vitamin B12 deficiency with these classic hematologic and neurologic signs and symptoms is rare (HughesJones & Wickramasinghe SN, 1996), low or marginal vitamin B12 status (serum B12 200300pg/mL [148221pmol/L]) without these symptoms is more common (i.e., up to 40% in Western populations), especially in individuals with low intakes of vitamin B12rich foods (NIH, 2024)

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