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According to the American and European recommendations, metformin is considered a first-line oral hypo-glycemic drug for controlling type 2 DM (T2DM) patients

It is the novel primary hypothesis that if PD symptoms from post-synaptic neuron damage develop, then compromise at any point in the electrical event chain, to include outside the post-synaptic dopamine neuron focus, may exacerbate and mimic PD symptoms and/or disease progression

Ghosh C, Nandi A, Basu S

This small addition of alcohol is a critical, non-negotiable element

However, as with any topically applied active ingredient, reactions can occur, particularly in individuals with sensitive skin or pre-existing scalp conditions such as seborrhoeic dermatitis or psoriasis
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