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While this study demonstrates that CPT-1 is dispensable for macrophage polarization to M2 and highlights the importance of CoA availability, future research using genetic approaches should shed more light on the importance of FAO in M2 polarization ( Another distinctive feature of IL4-treated macrophages is the up-regulation of CD36 by PPAR, a signaling receptor and FA transporter that participates in macrophage alternative activation (73)

[DOI] [PubMed] [Google Scholar] Lazzaro BP, Flores HA, Lorigan JG, Yourth CP

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