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Despite these therapies not being initially designed to trigger cellular senescence, it was discovered as early as 1998 that cisplatin could induce cellular senescence in head and neck cancer cells [53]
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Novartis is conducting a phase 3 trial for the use of Entresto in congestive heart failure in children, and plans to submit an application for supplementary approval in Europe this year
2017;136(6):e13761
[DOI] [PMC free article] [PubMed] [Google Scholar] Aguilar-Valles A, Rodrigue B, Matta-Camacho E (2020) Maternal immune activation and the development of dopaminergic neurotransmission of the offspring: relevance for schizophrenia and other psychoses
