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Description
Dietary glutamate does not influence levels of glutamate in the brain, nor does it play a role in neuroexcitation due to pathological conditions such as stroke

Food Sci Preserv

The answer comes down to bioavailability

however, in 3 subjects the onset of symptoms coincided with an increase in dosing frequency to tid and resolved when dosing was decreased to bid

PPI networks are distributed in complex diseases, including cancer and autoimmune disorders [463]