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10.1016/j.jep.2011.02.019 35 ColovicM
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[DOI] [PubMed] [Google Scholar] Manda VK, Avula B, Ali Z, Khan IA, Walker LA, Khan SI (2014b) Evaluation of in vitro absorption, distribution, metabolism, and excretion (ADME) properties of mitragynine, 7-hydroxymitragynine, and mitraphylline
While 5-FU primarily exerts its cytotoxic effects by disrupting DNA synthesis and inducing oxidative stress that exceeds a cytotoxic threshold 27 , cancer cells often counteract this oxidative stress by upregulating antioxidant defenses, leading to therapy resistance 10
