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Growth hormone secretagogues and physiology Thorner MO, et al

Nrf2 then translocates into the nucleus and binds to antioxidant response elements in the promoter region of several antioxidant genes, such as heme-oxygenase-1 and NADPH-quinone-oxidoreductase-1

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Under neuroinflammatory conditions, dysfunctional mitochondria release ROS and damage-associated molecular patterns (DAMPs) (53), activating microglia and astrocytes, and triggering the release of pro-inflammatory cytokines and chemokines (54), thereby exacerbating the damage

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