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Basic science knowledge obtained using both in vivo and in vitro models has not resulted in a dynamic development of novel drugs for CIPN and even a broader use of genetically-manipulated animals to study CIPN or assays that more closely resemble clinical picture of CIPN-related pain states has not increased the effectiveness of drug discovery and development of analgesics for CIPN

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However, natural conception was not a primary outcome in most studies, indeed most did not follow-up until pregnancy

Through a detailed medical consultation , we found that pregnancy and childbirth had caused overall skin laxity in the abdomen, rectus diastasis , and the presence of stretch marks