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These agents stimulate the production of insulin-like growth factor 1, promoting linear bone growth, increasing muscle mass, and altering lipid metabolism
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LGR4 and LGR5 are R-spondin receptors mediating Wnt/-catenin and Wnt/PCP signalling
Interestingly, BPTES also accelerated the production of pro-inflammatory cytokines produced by M1-like macrophages and boosted the immune responses [77, 78]
doi: 10.1002/glia.22397 136 ZhangYHandyDELoscalzoJ
