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While clinical trials are underway including the Mucoactives in Acute Respiratory failure: Carbocisteine and Hypertonic saline (MARCH) trial which is comparing the efficacy of carbocisteine and/or hypertonic versus standard care in critically unwell adults with a primary outcome of ventilator dependency time [154, 155], mechanistic exploration is necessary to identify the correct mucolytic for the correct patient given recent availability of rapid rheometers and development of multi-omics data analysis supported by artificial intelligence, future research should be aiming to individualise of the prescription and administration of currently used mucolytics matching them to mucus phenotypes (Fig

Katano et al

Konrad, T., Vicini, P., Kusterer, K., et al

It mainly comes from the recombinant expression system of Escherichia coli

Understanding the mechanisms of faecal microbiota transplantation