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According to the Symptoms, including severe pain during menstruation, heavy menstrual bleeding, back and pelvic pain, pain during intercourse, and, in some people, problems with fertility, occur when tissue similar to the endometrium, or uterine lining, grows outside the uterus

For instance, in the BioCycle Study ( n = 259 cycles in 62 women), E2 was positively associated with HDL-C in acute effects models and inversely associated with TC, LDL-C and TG in persistent effects models [125]

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In practice, this stabilization can cause some users to feel emotionally flat, experience less pleasure from daily activities, or feel a lack of strong emotions, especially when taken in high doses or over a long period

Clin Exp Immunol 103:9498