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Clinical samples and model studies further validate the clinical significance of the ACSL4LPCAT3 axis: in drug-resistant tumor tissues from patients with triple-negative breast cancer, ACSL4 expression levels were 2.8-fold higher than in sensitive tumors, and patients with high ACSL4 expression exhibited significantly enhanced responses to ferroptosis inducers combined with chemotherapy (37);In clear cell renal carcinoma cells, LPCAT3 expression is positively correlated with the levels of PE-AA and PE-AdA

Manley HJ, McClaran ML, Bedenbaugh A et al

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In female Daheng broilers, the upregulated expression of the PLIN2 gene was identified as being positively correlated with IMF contents in breast muscles