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However, the precise kinetics of selenium handover from Prx6 to SEPHS2, the structural determinants that govern selenium selectivity, and the extent to which Prx6 activity becomes rate-limiting during oxidative stress remain unclear

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The main exogenous inducers of skin aging are sunlight (photoaging), air pollution, tobacco smoke, unhealthy eating, exposure to extreme temperatures, stress and lack of sleep [8,9]

Moreover, HCC patients with low tumor expression of these key SAA enzymes had significantly worse prognosis than those with high expression of these genes (Supplementary Fig

But it wasnt always like that