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While QUR demonstrates pluripotent neuroprotective effects due to its poor solubility, bioavailability and instability in different in vitro and in vivo degenerative experimental models, its application in the pharmaceutical sector is restricted

Chronic ethanol intake also suppresses the activity of peroxisome proliferator-activated receptor-alpha (PPAR), which is a nuclear hormone receptor that upregulates the expression of many genes involved in the transport and beta-oxidation of free fatty acids (FFAs), including the gene encoding carnitine palmitoyltransferase 1 (CPT1) in mitochondria (Zhang et al., 2018a)

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This same study also found that exposing human airway epithelial cells (H292 cells) to electronic cigarette aerosols resulted in a dose-dependent increase in pro-inflammatory cytokines IL-8 and IL-6 (Lerner et al