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Melatonin is synthesized mainly in the pinealocytes of the pineal gland through the methylation of N-acetylserotonin, which is formed by the acetylation of 5-HT, a derivative of tryptophan, by aralkylamine N-acetyltransferase, followed by methylation via acetylserotonin-O-methyltransferase (ASMT)

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In addition to their catalytic properties, numerous plant GSTs also participate in the binding and transport of a wide range of small heterocyclic ligands such as flavonoids, including anthocyanins, and polyphenols through noncatalytic, ligandin properties (Sylvestre-Gonon et al., 2019)

In vitro, the mutant MOB1-K11R, which lacks acetylation, enhances the proliferation, migration and invasion of lung cancer cells, and in vivo, it accelerates tumor growth compared to wild-type MOB1 (105)

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