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Extensive A accumulation is observed in early and late endosomes in hippocampal neurons [1]

Masoumi, M., Salehi, M., Angaji, S

Some investigators have also found that diabetic complications and other diseases associated with AGEs may be treated with IGF-1 receptor antagonists and cholesterol-depleting agents ( IGF-1 receptor antagonists and cholesterol-lowering medications may be used to treat AGE-related disorders such as diabetic complications, according to some researchers ( In conclusion, our investigation discovered that circulating levels of IGF-1, IGF-1R, AGEs, and RAGE were high in CRC patients, suggesting a potential link between T2DM and CRC development