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Production MD simulations were carried out for 4 s for each complex, starting with PCU in the minor groove or PCU in the major groove, for a total of 8 s of free dynamics, sufficient to capture local Cu(II) coordination dynamics and base-pair conformational fluctuations without the need for enhanced sampling techniques

Even so, B vitamins and folate can alleviate the progression of AS by reducing plasma Hcy level and improving epigenetic factors (129)

When integrated with other regulatory mechanisms, these processes converge to form a highly intricate network of signaling that ultimately drives chemoresistance

Metabolic plasticity Metabolic plasticity is a defining hallmark of NSCLC that enables cancer cells to survive in fluctuating microenvironments