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population, and the limitations suggest that more investigations are needed to validate these outcomes

ADH and aldehyde dehydrogenases (ALDH) are phase I enzymes that catalyze the first and the second oxidation step, respectively [12,13]

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Two phase 3 trials BLOOM (Behavioral modification and Lorcaserin for Overweight and Obesity Management) and BLOSSOM (Behavioral modification and LOrcaserin Second Study for Obesity Management) evaluated obese and overweight patients to demonstrate the efficacy of lorcaserin (10 mg twice daily) over placebo [83.84]