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Evidence for brain glucose dysregulation in Alzheimer's disease

J Biol Chem 278:2109921104 [DOI] [PubMed] [Google Scholar] Suh PG, Park JI, Manzoli L, Cocco L, Peak JC, Katan M, Fukami K, Kataoka T, Yun S, Ryu SH

Although neurons activate compensatory NAD + salvage through nicotinamide phosphoribosyltransferase (NAMPT) [108], this pathway fails to offset PARP-1-driven NAD + catabolism during stroke [106], resulting in sustained sirtuin suppression and disrupted mitochondrial dynamics
