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In a study by Brookens et al., when the PPP was inhibited in murine splenic B cells by DHEA or 6-AN, production of IgM (only by 6-AN) and IgG1 (by DHEA and 6-AN) following LPS stimulation decreased in a dose-dependent manner

[DOI] [PMC free article] [PubMed] [Google Scholar] 186.Bao LH, Zhang YN, Zhang JN, et al

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4 Conversely, BPC-157 reversed L-NAME-induced hypertension in rat models an effect consistent with eNOS-dependent vasodilation rather than simple anti-inflammatory activity

These actions are likely due to the potential of BPC-157 to simulate vasodilatation and angiogenesis (new blood vessel formation) due to its action on peptidergic growth factors such as endothelial growth factor, Consequently, the peptide has demonstrated significant protective effects against gastric mucosal injury in rat models