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Lastly, bioavailability, which determines how much drug enters the systemic circulation and pharmacokinetic equations that form the quantitative basis of drug therapy are discussed

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10.1007/s11101-014-9373-1 23 BeyersmannD.HaaseH

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The gutbrain axis is not only a physiological connection between the hypothalamus of the brain and the large intestine, but also serves as a network that interacts with the immune and endocrine system through the exchange of neurotransmitters, metabolites, and cytokines [12]