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Description
Malondialdehyde (MDA) and inflammatory cytokines concentration have been reduced after melatonin treatment in critical situations such as asphyxia, sepsis, and surgery [160-162]

One may however assume that GPX4 inhibition would promote M1 polarization of macrophages at the expense of M2 polarization

The raw Illumina sequencing reads generated from the paired-end library were subjected to quality-filtered using fastp v0.23.0

Phospholipid oxidation generates potent anti-inflammatory lipid mediators that mimic structurally related pro-resolving eicosanoids by activating Nrf2

In addition to this, astrocytes are known to display high metabolic plasticity in terms of glucose utilization, when compared to neurons (Pellerin and Magistretti, 1994
