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doi: 10.1073/pnas.1316569111

At 28 days after onset of hypoperfusion, rats treated with L-carnitine had increased phosphorylated Akt and mammalian target of rapamycin (mTOR), as well as increased levels of phosphorylated high-molecular weight neurofilament (pNFH) compared to vehicle treated rats [86]

There are also important sex differences in multiple IR-related chronic syndromes, such as obesity, diabetes, and cardiovascular disease that should be further explored in connection to LAC levels

Faverzani JL, Hammerschmidt TG, Mescka CP, Guerreiro G, Lopes FF, Delgado CA, de Moura Coelho D, Sitta A, Deon M, Wajner M, Vargas CR (2023) Increased cytokine levels induced by high phenylalanine concentrations in late diagnosis PKU patients compared to early diagnosis: anti-inflammatory effect of L-carnitine

In a clinically relevant model of global ischemia after canine cardiac arrest, treatment with ALCAR reduced the amount of protein carbonyls which are formed after oxidative stress in brain [104]